Chicago White Sox at Cleveland Guardians odds, picks and predictions

The Chicago White Sox (41-43) and Cleveland Guardians (41-42) clash Monday at 7:10 p.M. ET as they swing into a 4-game set at Progressive Field. Let’s analyze Tipico Sportsbook’s lines around the White Sox vs. Guardiansodds with MLB picks and predictions.

Season series: Cleveland leads 4-1.

The White Sox have allowed 4.73 runs per game for the season, but they have cruised along with solid pitching of late. Chicago owns a 3.57 ERA, 1.20 WHIP in its last 14 games.

On June 22, the Guardians were 8 games over .500 (36-28) and in 1st place in the AL Central. Since that date, Cleveland is a paltry 5-14. The club’s bats have fallen silent at home as the Guardians own a .602 home OPS in that 19-game stretch.

White Sox at Guardians projected starters

RHP Lance Lynn vs. RHP Cal Quantrill.

Lynn (1-1, 5.33 ERA) makes his 6th start of 2022. He has a 1.33 WHIP, 2.3 BB/9 and 8.7 K/9 in 27 IP.

  • Spent the first couple of months of the season on the IL (knee).
  • Allowed 6 runs 3 starts back and 5 in his last start. He split those 2 turns with 6 shutout innings at San Francisco.
  • Current Cleveland batters own an aggregate .804 OPS against him.
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    Quantrill (4-5, 3.86 ERA) makes his 16th start. He has a 1.30 WHIP, 2.7 BB/9 and 5.6 K/9 in 88 2/3 IP.

  • Has a 2.25 ERA in 4 career starts against Chicago.
  • Owns a fine 2.97 ERA over his last 6 starts at home.
  • White Sox at Guardians odds and lines

    Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated 8:36 a.M. ET.

  • Money line: White Sox -115 (bet $100 to win $115) | Guardians -105 (bet $105 to win $100).
  • Run line (RL): White Sox -1.5 (+135) | Guardians +1.5 (-170).
  • Over/Under (O/U): 9.5 (O: +100 | U: -125).
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    White Sox at Guardians picks and predictions


    White Sox 5, Guardians 3.

    Money line

    Quantrill has posted some generous rates around the margins, and Lynn’s small-sample-size numbers swing the other way. The Chicago right-hander struggled in his last start, but that was against a better Minnesota offense and on the heels of back-to-back high-pitch-count efforts. And late-career Lynn has been solid against lefty bats which is a big key against this Cleveland offense.


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    Run line/Against the spread

    Chicago -1.5 (+135) has some slight lean to it – would be worth some action at +140 or better.


    Both clubs have some underlying-analytics drag in their batting numbers. And Statcast quality-of-contact figures also call for both offenses to cool off.

    But with two fly-ball pitchers on a warm night with a batter’s breeze in the forecast chips away at potential value. So does the pricing here. STEER CLEAR.

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